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Organo Se BTSAs Revolutionizing Chemist

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Organo-Se species represent a type of increasingly important core motif widely found in endogenous proteins and bioactive  small molecules . Consequently, exploring their structural diversity to entrust their powerful potential has emerged as an important endeavor in basic research, but it remains extremely limited and highly challenging. Here, we realize either racemic or  asymmetric synthesis  toward a class of organo-Se species, namely benzothiaselenazole-1-oxides (BTSAs), and reveal its diversified applications. For example, we identified that BTSAs can be recognized as the click selenylation reagents, which not only enabled on-plate modular construction of parallel (1,066 examples) and DNA-encoded (261 examples) indole-C 3 -selenide libraries but also provided the site-specific modification of sulfhydryl-containing chemicals for application in anti-COVID-19  drug discovery  and bioorthogonal labeling-based HER2 fluorescence imaging analysis. ...

Machine Learning in 3D DEM Revolution!

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The detection and resolution of contacts among irregular-shaped particles pose significant challenges in the discrete element method (DEM) and recent advancements have introduced a machine learning-enabled approach specifically tailored for contact detection and resolution in two dimensions. Building upon this progress, this paper extends the application of machine learning-enabled DEM to encompass the more complex and realistic three-dimensional (3D) scenario. Particles are modeled using a polyhedral representation with arbitrary shapes, and contact behavior is governed by an energy-conserving contact model based on contact volumes. The efficacy of the machine learning-enabled 3D DEM is evaluated through comparative analyses of computational time and simulation results across individual contact as well as whole DEM simulations against those obtained from the conventional DEM. World Top Scientists Awards Visit Our Website 🌐: worldtopscientists.com Nominate Now📝: https://worldtopscie...

Meet the Chemical Researchers Changing the World!

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A diverse group of chemical researchers in a high-tech laboratory, wearing lab coats and safety goggles, working with beakers, test tubes, and advanced equipment. Some are analyzing chemical reactions, while others are using futuristic tools like AI-driven analysis screens. The setting is bright and modern, symbolizing innovation and progress. Chemical researchers are at the forefront of groundbreaking discoveries that shape our world. From developing sustainable energy solutions and life-saving pharmaceuticals to creating advanced materials and tackling environmental challenges, these scientists are transforming industries and improving lives. Their work drives innovation in medicine, technology, and sustainability, making a lasting impact on society. World Top Scientists Awards Visit Our Website 🌐: worldtopscientists.com Nominate Now📝: https://worldtopscientists.com/award-nomination/?ecategory=Awards&rcategory=Awardee Contact us ✉️: contact@worldtopscientists.com

Flower rich Road Verges A Blooming Boos #sciencefather #researchawards ...

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Getting computers to do our bidding has always been a bit mysterious to those of us not steeped in machine code, operating systems, and programming. We were content, if that is the right word, to muddle through command-line interfaces (CLIs) and then GUIs (graphical user interfaces), the ones with the files and folders metaphor as our means of interacting with digital technologies. But two things have changed in ways that indicate the need for a broader cadre of leaders to engage with one another. It can’t just be technologists any longer. One is the advent of machine-learning, a set of techniques developed in Artificial Intelligence (AI) that has vastly improved credit card fraud detection, for example. Farmers are now able to use automated farm vehicles to plough and sow using pinpoint-accurate GPS systems. The second change is the kind of decision-making we are willing to accord, or have accorded, our technologies. Should we allow our technologies to act on those decisions without h...

Fire at Paradise town depot brought under control

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A fire at the Paradise town depot has been brought under control. Smoke was seen billowing from a building in the area of the town hall around 4:20 p.m. Sunday. Town spokesperson Diane Keough said in a statement that a fire occurred in the depot area of the Paradise town hall. First responders arrived and brought the fire under control. Keough said that no one was in the town hall or depot during the fire and there are no injuries reported. The town asked residents to avoid the area for a time. World Top Scientists Awards Visit Our Website 🌐: worldtopscientists.com Nominate Now📝: https://worldtopscientists.com/award-nomination/?ecategory=Awards&rcategory=Awardee Contact us ✉️: contact@worldtopscientists.com #Sciencefather #ResearchAwards #WorldTopScientistsAwards #professors #doctor #researchers #phd #ParadiseTown #FireSafety #EmergencyResponse #FireUnderControl #DepotFire #LocalNews #CommunityAlert Here Connected With: ===================== Facebook:  www.fac...

Giving drug researchers control of their data

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Iguess I’ve been digitizing for my entire career, 20 years,” said Michael Montello, senior vice president of R&D technology at GlaxoSmithKline. “I remember the first data warehouse I implemented in discovery . . . And here we are still talking about digital transformation.” Montello was reminiscing at the Bio-IT World Conference in September, where he discussed the past 3 years of GSK’s digitization initiative. Peers from Pfizer, Roche, and Eli Lilly and Company joined him, describing similar programs at their firms in drug discovery data management. Their discussion had a familiar ring to it: break down function silos, establish central data management, develop standard terminologies. In fact, a regular conference attendee may well have shared Montello’s observation: “Here we are again.” But there is no question that equipping labs with information technology is a rapidly changing endeavor given the now-ubiquitous use of cloud computing and the soon-to-be ubiquitous deployment of ...

Clinical Researcher Do

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Clinical researchers are responsible for ensuring these trials are conducted in an ethical manner whilst following good clinical practice and ensuring all team members are compliant with strict rules and regulations. They are required to diligently handle documents and materials in a safe and secure manner. Overall, the researchers are responsible for recruiting and screening patients, maintaining patient care in terms of health and progress, and then submitting the findings to the sponsoring organisation upon completion. To work in the field, clinical researchers must have at least a master's degree in science or medicine, with some positions requiring a PhD and relevant specialist experience. Employers include hospitals, universities, pharmaceutical labs and government departments. Key skills are critical thinking, complex problem solving and decision making, along with excellent numerical, written and verbal communication skills. Overall, the role of a clinical researcher involv...